One-step Derivation of Functional Mesenchymal Stem Cells from Human Pluripotent Stem Cells
Yan Zhou, Jinqi Liao(Shenzhen University Health Science Center), Chongzhou Fang, Cuiping Mo, Guangqian Zhou(Shenzhen University Health Science Center), Yonglun Luo(Aarhus University)
Cited by 14Open Access
Abstract
(adipogenesis, osteogenesis and chondrogenesis). As compared with other available protocols, our protocol can be applied to generate a large number of MSCs from hPSCs with high efficiency, low-cost manner, moreover, not involving embryoid body, mouse feeder-cell, flow sorting, and pathway inhibitors (such as SB203580 and SB431542). We believe that this protocol could provide a robust platform to reach the future demand for producing the industrial scale of MSC from hPSCs for autologous cell-based therapy.