Perspective: The promise of multi-cellular engineered living systems

Roger D. Kamm(Massachusetts Institute of Technology), Rashid Bashir(University of Illinois Urbana-Champaign), Natasha Arora(Massachusetts Institute of Technology), Roy D. Dar(University of Illinois Urbana-Champaign), Martha U. Gillette(University of Illinois Urbana-Champaign), Linda G. Griffith(Massachusetts Institute of Technology), Melissa L. Kemp(Georgia Institute of Technology), Kathy Kinlaw(Emory University), Michael Levin(Tufts University), Adam C. Martin(Massachusetts Institute of Technology), Todd C. McDevitt(Gladstone Institutes), Robert M. Nerem(Georgia Institute of Technology), Mark J. Powers(Thermo Fisher Scientific (United States)), Taher A. Saif(University of Illinois Urbana-Champaign), James Sharpe(European Molecular Biology Laboratory), Shuichi Takayama(Georgia Institute of Technology), Shoji Takeuchi(The University of Tokyo), Ron Weiss(Massachusetts Institute of Technology), Kaiming Ye(Binghamton University), Hannah Yevick(Massachusetts Institute of Technology), Muhammad H. Zaman(Boston University)
APL Bioengineering
October 11, 2018
10.1063/1.5038337
Cited by 162Open Access
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Abstract

Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered.

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