HLA common and well‐documented alleles in China

Yunlei He(Blood Center of Zhejiang Province), Jianping Li, W. Mao(Chongqing Emergency Medical Center), Ding‐yu Zhang(Beijing Red Cross Blood Center), M. Liu(Shaanxi Blood Center), X. Shan(Beijing Red Cross Blood Center), B. Zhang(Beijing Red Cross Blood Center), C.‐F. Zhu(Blood Center of Zhejiang Province), Jie Shen(Jiangsu Province Hospital), Zhihui Deng(Shenzhen Blood Center), Ziqing Wang(HBIS (China)), Wang Yu(Beijing Red Cross Blood Center), Qili Chen(Chinese Academy of Medical Sciences & Peking Union Medical College), Wentao Guo, P. Su(Kunming University), Ruyan Lv(Beijing Red Cross Blood Center), G. Li(Blood Center of Zhejiang Province), G. Li(Blood Center of Zhejiang Province), Bin Pei(Xiamen Blood Center), L. Jiao(Changchun Obstetrics and Gynecology Hospital), Gang Shen(Wuhan Blood Center), Ying Liu(Beijing Red Cross Blood Center), Zhihui Feng(Qingdao Center of Resource Chemistry and New Materials), Yuping Su(Beijing Red Cross Blood Center), Yue Xie(Changsha University), Wei Di(Beijing Red Cross Blood Center), Xiao Liu(China National Chemical Corporation (China)), Xiaoqin Yang(BGI Group (China)), J. Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Jun Qi(Shaanxi Blood Center), Qianwen Liu(National Marrow Donor Program), Ying Han(National Marrow Donor Program), Jin He(Soochow University), Jianping Cai(Beijing Geriatric Hospital), Z. Zhang(Beijing Red Cross Blood Center), Faming Zhu(Blood Center of Zhejiang Province), Dan Du(National Marrow Donor Program)
HLA
August 7, 2018
10.1111/tan.13358
Cited by 137

Abstract

The American Society for Histocompatibility and Immunogenetics HLA common and well-documented (CWD) catalog, CWD 2.0.0 catalog and European Federation for Immunogenetics (EFI) CWD catalog have been published, which are useful for improving the accuracy of HLA genotyping in laboratories. Here, we studied the Chinese HLA CWD catalog. A total of 812 211 unrelated volunteer donors from the China Marrow Donor Program (CMDP) were analyzed. Six hundred seventy-six alleles at the HLA-A, -B, -C, -DRB1, and -DQB1 loci were defined as CWD alleles in the Chinese population, including 159 common and 517 well-documented alleles. The distribution of HLA alleles in the Chinese CWD catalog is different from that in the EFI CWD catalog. Thirty-two percent (215/676) of CWD alleles in the Chinese CWD catalog are shared with those in the EFI CWD catalog. Fifty-six percent (380/676) of alleles in the Chinese CWD catalog are not found in the EFI CWD catalog, while 655 alleles in the EFI CWD catalog are neither common nor well-documented alleles in the Chinese CWD catalog. The Chinese CWD catalog described in this study may help to improve high-resolution histocompatibility testing for CMDP-accredited laboratories in China. However, to accommodate an increasing number of HLA alleles, this Chinese CWD catalog should be regularly updated.

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