Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration
Alban Latrémolière(Boston Children's Hospital), Long Cheng(Boston Children's Hospital), Michelle M. DeLisle(Boston Children's Hospital), Chen Wu(Boston Children's Hospital), Sheena Chew(Boston Children's Hospital), Elizabeth Hutchinson(Henry M. Jackson Foundation), Andrew Sheridan(Boston Children's Hospital), C Alexandre(Beth Israel Deaconess Medical Center), Frédéric Latrémolière(University of Denver), Shu‐Hsien Sheu(Boston Children's Hospital), Sara Golidy(Boston Children's Hospital), Takao Omura(Boston Children's Hospital), Eric A. Huebner(Boston Children's Hospital), Yanjie Fan(Boston Children's Hospital), Mary C. Whitman(Boston Children's Hospital), Elaine Nguyen(Boston Children's Hospital), Crystal Hermawan(Boston Children's Hospital), Carlo Pierpaoli(Henry M. Jackson Foundation), Max A. Tischfield(Boston Children's Hospital), Clifford J. Woolf(Boston Children's Hospital), Elizabeth C. Engle(Boston Children's Hospital)
Cited by 175Open Access
Abstract
and wild-type mice. Despite similar levels of total β-tubulin, adult dorsal root ganglia lacking TUBB3 have decreased growth cone microtubule dynamics and a decreased neurite outgrowth rate of 22% in vitro and in vivo. The effect of the 22% slower growth rate is exacerbated for sensory recovery, where fibers must reinnervate the full volume of the skin to recover touch function. Overall, these data reveal that, while TUBB3 is not required for formation of the nervous system, it has a specific role in the rate of peripheral axon regeneration that cannot be replaced by other β-tubulins.
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