Platelets kill circulating parasites of all major Plasmodium species in human malaria

Steven Kho(Charles Darwin University), Bridget E. Barber(Charles Darwin University), Edison Johar(Australian National University), Benediktus Andries(State University of Papua), Jeanne Rini Poespoprodjo(Universitas Gadjah Mada), Enny Kenangalem(State University of Papua), Kim A. Piera(Charles Darwin University), Anna Ehmann(Australian National University), Ric N. Price(Charles Darwin University), Timothy William(Ministry of Health), Tonia Woodberry(Charles Darwin University), Simon Foote(Australian National University), Gabriela Minigo(Charles Darwin University), Tsin Wen Yeo(Charles Darwin University), Matthew J. Grigg(Charles Darwin University), Nicholas M. Anstey(Charles Darwin University), Brendan J. McMorran(Australian National University)
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Abstract

Key Points Platelets directly interact with and kill circulating Plasmodium parasites in patients with malaria to help control parasitemia. In vitro platelet antiplasmodicidal activity against P knowlesi involves platelet–cell binding and intracellular accumulation of PF4.


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