P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
Alazne Zabala(University of the Basque Country), Nuria Vázquez‐Villoldo(University of the Basque Country), Björn Rissiek(Universität Hamburg), Jon Gejo(University of the Basque Country), Abraham Martín(CIC biomaGUNE), Aitor Palomino(University of the Basque Country), Alberto Pérez‐Samartín(University of the Basque Country), Krishna R. Pulagam(CIC biomaGUNE), Marco Lukowiak(Universität Hamburg), Estibaliz Capetillo‐Zarate(Ikerbasque), Jordi Llop(CIC biomaGUNE), Tim Magnus(Universität Hamburg), Friedrich Koch‐Nolte(Universität Hamburg), Francois Rassendren(Centre National de la Recherche Scientifique), Carlos Matute(University of the Basque Country), Marı́a Domercq(University of the Basque Country)
Cited by 193Open Access
Abstract
and remyelination after lysolecithin-induced demyelination. Conversely, potentiation of P2X4R signaling by the allosteric modulator ivermectin (IVM) favored a switch in microglia to an anti-inflammatory phenotype, potentiated myelin phagocytosis, promoted the remyelination response, and ameliorated clinical signs of EAE Our results provide evidence that P2X4Rs modulate microglia/macrophage inflammatory responses and identify IVM as a potential candidate among currently used drugs to promote the repair of myelin damage.
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