Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes
Lauren Fong(Sanford Consortium for Regenerative Medicine), Max M. Yang(University of California, San Diego), Rodrigo dos Santos Chaves(University of California, San Diego), Sol M. Reyna(University of California, San Diego), Vanessa F. Langness(Sanford Consortium for Regenerative Medicine), Grace Woodruff(Sanford Consortium for Regenerative Medicine), Elizabeth A. Roberts(University of California, San Diego), Jessica E. Young(University of Washington), Lawrence S.B. Goldstein(Sanford Consortium for Regenerative Medicine)
Cited by 75Open Access
Abstract
astrocytes reversed the LDL and Aβ endocytosis defects. In conclusion, FL APP is involved in the endocytosis of LDL receptor ligands and is required for proper cholesterol homeostasis and Aβ clearance in human astrocytes.
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