The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma

Leo Rasche(Myeloma UK), Edgardo J. Angtuaco(University of Arkansas for Medical Sciences), Terri L. Alpe(Myeloma UK), Grant Gershner(Myeloma UK), James E. McDonald(University of Arkansas for Medical Sciences), Rohan Samant(University of Arkansas for Medical Sciences), Manoj Kumar(University of Arkansas for Medical Sciences), Rudy Van Hemert(University of Arkansas for Medical Sciences), Joshua Epstein(Myeloma UK), Shayu Deshpande(Myeloma UK), Ruslana G. Tytarenko(Myeloma UK), Shmuel Yaccoby(Myeloma UK), Jens Hillengaß(Roswell Park Comprehensive Cancer Center), Sharmilan Thanendrarajan(Myeloma UK), Carolina Schinke(Myeloma UK), Frits van Rhee(Myeloma UK), Maurizio Zangari(Myeloma UK), Brian A. Walker(Myeloma UK), Bart Barlogie(Myeloma UK), Gareth J. Morgan(Myeloma UK), Faith E. Davies(Myeloma UK), Niels Weinhold(Myeloma UK)
Blood
May 21, 2018
10.1182/blood-2018-04-842880
Cited by 117Open Access
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Abstract

were associated with poor progression-free survival (PFS) and overall survival (OS; median, 2.3 and 3.6 years, respectively). This pattern, seen in 13.8% of patients, was independent of the Revised International Staging System (RISS), gene expression profiling (GEP)-based risk score, gain(1q), or extramedullary disease (hazard ratio, 2.7 and 2.2 for PFS and OS in multivariate analysis, respectively). The number of FLs lost its negative impact on outcome after adjusting for FL size. In conclusion, the presence of at least 3 large FL is a feature of high risk, which can be used to refine the diagnosis of this type of disease behavior and as an entry criterion for risk-stratified trials.

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