Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
Ying Yang(Chinese Academy of Sciences), Phillip J. Hsu(Howard Hughes Medical Institute), Yusheng Chen(Chinese Academy of Sciences), Yun‐Gui Yang(Chinese Academy of Sciences)
Cited by 1,779Open Access
Abstract
Abstract N 6 -methyladenosine (m 6 A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m 6 A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m 6 A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.