Role of metabolism in cancer cell radioresistance and radiosensitization methods

Le Tang(Third Xiangya Hospital), Fang Wei(Central South University), Yingfen Wu(Central South University), Yi He(Hunan Cancer Hospital), Lei Shi(Central South University), Fang Xiong(Central South University), Zhaojian Gong(Central South University), Can Guo(Central South University), Xiayu Li(Xiangya Hospital Central South University), Hao Deng(Third Xiangya Hospital), Ke Cao(Central South University), Ming Zhou(Third Xiangya Hospital), Bo Xiang(Central South University), Xiaoling Li(Central South University), Yong Li(Central South University), Guiyuan Li(Xiangya Hospital Central South University), Wei Xiong(Central South University), Zhaoyang Zeng(Central South University)
Journal of Experimental & Clinical Cancer Research
April 23, 2018
10.1186/s13046-018-0758-7
Cited by 419Open Access
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Abstract

BACKGROUND: Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably changes, which may result in the development of resistance to radiation. MAIN BODY: Here, we discussed the relationships between radioresistance and mitochondrial and glucose metabolic pathways, aiming to elucidate the interplay between the tumor cell metabolism and radiotherapy resistance. In this review, we additionally summarized the potential therapeutic targets in the metabolic pathways. SHORT CONCLUSION: The aim of this review was to provide a theoretical basis and relevant references, which may lead to the improvement of the sensitivity of radiotherapy and prolong the survival of cancer patients.

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