ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade

Jianfeng Shen; Zhenlin Ju; Zhao Wei; Lulu Wang; Yang Peng; Zhongqi Ge; Zachary D. Nagel; Jun Zou; Chen Wang; Prabodh Kapoor; Xiangyi Ma; Ding Ma; Jiyong Liang; Shumei Song; Jinsong Liu; Leona D. Samson; Jaffer A. Ajani; Guo‐Min Li; Han Liang; Xuetong Shen; Gordon B. Mills; Guang Peng

doi:10.1038/s41591-018-0012-z

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade

Jianfeng Shen(The University of Texas MD Anderson Cancer Center), Zhenlin Ju(The University of Texas MD Anderson Cancer Center), Zhao Wei(The University of Texas MD Anderson Cancer Center), Lulu Wang(The University of Texas MD Anderson Cancer Center), Yang Peng(The University of Texas MD Anderson Cancer Center), Zhongqi Ge(The University of Texas MD Anderson Cancer Center), Zachary D. Nagel(Center for Environmental Health), Jun Zou(Tongji Hospital), Chen Wang(Tongji Hospital), Prabodh Kapoor(The University of Texas MD Anderson Cancer Center), Xiangyi Ma(Cancer Research Center), Ding Ma(Cancer Research Center), Jiyong Liang(The University of Texas MD Anderson Cancer Center), Shumei Song(The University of Texas MD Anderson Cancer Center), Jinsong Liu(The University of Texas MD Anderson Cancer Center), Leona D. Samson(Center for Environmental Health), Jaffer A. Ajani(The University of Texas MD Anderson Cancer Center), Guo‐Min Li(The University of Texas Southwestern Medical Center), Han Liang(The University of Texas MD Anderson Cancer Center), Xuetong Shen(The University of Texas MD Anderson Cancer Center), Gordon B. Mills(The University of Texas MD Anderson Cancer Center), Guang Peng(The University of Texas MD Anderson Cancer Center)

Nature Medicine

May 1, 2018

10.1038/s41591-018-0012-z

Cited by 568

Abstract

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