An anatomic transcriptional atlas of human glioblastoma
Ralph B. Puchalski(Allen Institute for Brain Science), Nameeta Shah(Mazumdar Shaw Medical Foundation), Jeremy A. Miller(Allen Institute for Brain Science), Rachel Dalley(Allen Institute for Brain Science), Steve R. Nomura(Swedish Medical Center), Jae-Guen Yoon(Swedish Medical Center), Kimberly A. Smith(Allen Institute for Brain Science), Michael Lankerovich(Swedish Medical Center), Darren Bertagnolli(Allen Institute for Brain Science), Kris Bickley(Allen Institute for Brain Science), Andrew F. Boe(Allen Institute for Brain Science), Krissy Brouner(Allen Institute for Brain Science), Stephanie Butler(Allen Institute for Brain Science), Shiella Caldejon(Allen Institute for Brain Science), Mike Chapin(Allen Institute for Brain Science), Suvro Datta(Allen Institute for Brain Science), Nick Dee(Allen Institute for Brain Science), Tsega Desta(Allen Institute for Brain Science), Tim Dolbeare(Allen Institute for Brain Science), Nadezhda Dotson(Allen Institute for Brain Science), Amanda Ebbert(Allen Institute for Brain Science), David Feng(Allen Institute for Brain Science), Xueli Feng(Radiant Research (United States)), Michael Fisher(Allen Institute for Brain Science), Garrett Gee(Allen Institute for Brain Science), Jeff Goldy(Allen Institute for Brain Science), Lindsey Gourley(Allen Institute for Brain Science), Benjamin W. Gregor(Allen Institute for Brain Science), Guangyu Gu(Allen Institute for Brain Science), Nika Hejazinia(Allen Institute for Brain Science), John G. Hohmann(Allen Institute for Brain Science), Parvinder Hothi(Swedish Medical Center), Robert Howard(Allen Institute for Brain Science), Kevin Joines(Allen Institute for Brain Science), Ali Kriedberg(Allen Institute for Brain Science), Leonard Kuan(Allen Institute for Brain Science), Chris Lau(Allen Institute for Brain Science), Felix Lee(Allen Institute for Brain Science), Hwahyung Lee(Swedish Medical Center), Tracy Lemon(Allen Institute for Brain Science), Fuhui Long(Allen Institute for Brain Science), Naveed Mastan(Allen Institute for Brain Science), Erika Mott(Allen Institute for Brain Science), Chantal Murthy(Swedish Medical Center), Kiet Ngo(Allen Institute for Brain Science), Eric N. Olson(Allen Institute for Brain Science), Melissa Reding(Allen Institute for Brain Science), Zack L. Riley(Allen Institute for Brain Science), David Rosen(Allen Institute for Brain Science), David Sandman(Allen Institute for Brain Science), Nadiya V. Shapovalova(Allen Institute for Brain Science), Clifford R. Slaughterbeck(Allen Institute for Brain Science), Andrew Sodt(Allen Institute for Brain Science), Graham Stockdale(Allen Institute for Brain Science), Aaron Szafer(Allen Institute for Brain Science), Wayne Wakeman(Allen Institute for Brain Science), Paul Wohnoutka(Allen Institute for Brain Science), Steven J. White(US Forest Service), D. C. B. Marsh(US Forest Service), Robert Rostomily(Houston Methodist), Lydia Ng(Allen Institute for Brain Science), Chinh Dang(Allen Institute for Brain Science), Allan R. Jones(Allen Institute for Brain Science), Bart P. Keogh(Radiant Research (United States)), Haley Gittleman(Case Western Reserve University), Jill S. Barnholtz‐Sloan(Case Western Reserve University), Patrick J. Cimino(University of Washington), Megha Uppin(Nizam's Institute of Medical Sciences), C. Dirk Keene(University of Washington), Farrokh Farrokhi(Virginia Mason Medical Center), Justin D. Lathia(Cleveland Clinic), Michael E. Berens(Translational Genomics Research Institute), Antonio Iavarone(Cancer Genetics (United States)), Amy Bernard(Allen Institute for Brain Science), Ed S. Lein(Allen Institute for Brain Science), John W. Phillips(Allen Institute for Brain Science), Steven Rostad(Ennetix (United States)), Charles Cobbs(Swedish Medical Center), Michael Hawrylycz(Allen Institute for Brain Science), Greg Foltz(Swedish Medical Center)
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Abstract
Anatomically correct tumor genomics Glioblastoma is the most lethal form of human brain cancer. The genomic alterations and gene expression profiles characterizing this tumor type have been widely studied. Puchalski et al. created the Ivy Glioblastoma Atlas, a freely available online resource for the research community. The atlas, a collaborative effort between bioinformaticians and pathologists, maps molecular features of glioblastomas, such as transcriptional signatures, to histologically defined anatomical regions of the tumors. The relationships identified in this atlas, in conjunction with associated databases of clinical and genomic information, could provide new insights into the pathogenesis, diagnosis, and treatment of glioblastoma. Science , this issue p. 660