Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target

Dabin Liu(Chinese University of Hong Kong), Chi Chun Wong(Chinese University of Hong Kong), Li Fu(Chinese University of Hong Kong), Huarong Chen(Chinese University of Hong Kong), Liuyang Zhao(Chinese University of Hong Kong), Chuangen Li(Chinese University of Hong Kong), Yunfei Zhou(Chinese University of Hong Kong), Yanquan Zhang(Chinese University of Hong Kong), Weiqi Xu(Chinese University of Hong Kong), Yidong Yang(Sun Yat-sen University), Bin Wu(Sun Yat-sen University), Gong Cheng(Chinese University of Hong Kong), Paul B.S. Lai(Chinese University of Hong Kong), Nathalie Wong(Chinese University of Hong Kong), Joseph J.�Y. Sung(Chinese University of Hong Kong), Jun Yu(Chinese University of Hong Kong)
Science Translational Medicine
April 18, 2018
10.1126/scitranslmed.aap9840
Cited by 277Open Access
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Abstract

as an oncogene in NAFLD-HCC and propose that repurposing SQLE inhibitors may be a promising approach for the prevention and treatment of NAFLD-HCC.

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