Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation
Petra Kotzbeck(University of Graz), Antonio Giordano(Marche Polytechnic University), Eleonora Mondini(Marche Polytechnic University), Incoronata Murano(Marche Polytechnic University), Ilenia Severi(Marche Polytechnic University), Wiebe Venema(Marche Polytechnic University), Maria Paola Cecchini(University of Verona), Erin E. Kershaw(University of Pittsburgh), Giorgio Barbatelli(Marche Polytechnic University), Guenter Haemmerle(University of Graz), Rudolf Zechner(University of Graz), Saverio Cinti(Marche Polytechnic University)
Cited by 284Open Access
Abstract
-deficient mice was associated to a strong inflammatory response and NLRP3 inflammasome activation. Altogether, the present findings suggest that converted enlarged brown adipocytes are highly prone to death, which, by promoting inflammation in whitened BAT, may contribute to the typical inflammatory state seen in obesity.
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