Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills(Dana-Farber Cancer Institute), Dylan G. Ryan(Trinity College Dublin), Hiran A. Prag(University of Cambridge), Dina Dikovskaya(University of Dundee), Deepthi Menon(Trinity College Dublin), Zbigniew Zasłona(Trinity College Dublin), Mark P. Jedrychowski(Dana-Farber Cancer Institute), Ana S.H. Costa(MRC Cancer Unit), Maureen Higgins(University of Dundee), Emily Hams(Trinity College Dublin), John Szpyt(Harvard University), Marah C. Runtsch(Trinity College Dublin), Martin King(University of Cambridge), Joanna F. McGouran(Trinity College Dublin), Román Fischer(University of Oxford), Benedikt M. Kessler(University of Oxford), Anne F. McGettrick(Trinity College Dublin), Mark Hughes(Trinity College Dublin), Richard G. Carroll(Trinity College Dublin), Lee M. Booty(GlaxoSmithKline (United Kingdom)), Elena V. Knatko(University of Dundee), Paul J. Meakin(University of Dundee), Michael L.J. Ashford(University of Dundee), Louise K. Modis(GlaxoSmithKline (United Kingdom)), Gino Brunori(GlaxoSmithKline (United Kingdom)), Daniel C. Sévin(GlaxoSmithKline (Germany)), Padraic G. Fallon(Trinity College Dublin), Stuart T. Caldwell(University of Glasgow), Edmund R.S. Kunji(MRC Mitochondrial Biology Unit), Edward T. Chouchani(Harvard University), Christian Frezza(Hutchison/MRC Research Centre), Albena T. Dinkova‐Kostova(University of Dundee), Richard C. Hartley(University of Glasgow), Michael P. Murphy(University of Cambridge), Luke O'neill(GlaxoSmithKline (United Kingdom))
Nature
March 27, 2018
Cited by 1,815Open Access

Abstract


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