PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders
Xavier Palomer(Hospital Sant Joan de Déu Barcelona), Emma Barroso(Hospital Sant Joan de Déu Barcelona), Javier Pizarro‐Delgado(Hospital Sant Joan de Déu Barcelona), Lucía Peña(Hospital Sant Joan de Déu Barcelona), Gaia Botteri(Hospital Sant Joan de Déu Barcelona), Mohammad Zarei(Hospital Sant Joan de Déu Barcelona), David Aguilar-Recarte(Hospital Sant Joan de Déu Barcelona), Marta Montori-Grau(Hospital Sant Joan de Déu Barcelona), Manuel Vázquez‐Carrera(Hospital Sant Joan de Déu Barcelona)
Cited by 99Open Access
Abstract
Research in recent years on peroxisome proliferator-activated receptor (PPAR)β/δ indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARβ/δ activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPARβ/δ regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPARβ/δ as a treatment for human metabolic disorders.
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