A Non-integrating Lentiviral Approach Overcomes Cas9-Induced Immune Rejection to Establish an Immunocompetent Metastatic Renal Cancer Model

Junhui Hu(University of California, Los Angeles), Shiruyeh Schokrpur(University of California, Los Angeles), Maani M. Archang(University of California, Los Angeles), Kip Hermann(University of California, Los Angeles), Allison C. Sharrow(University of California, Los Angeles), Prateek Khanna(Beth Israel Deaconess Medical Center), Jesse Novak(Brigham and Women's Hospital), Sabina Signoretti(Brigham and Women's Hospital), Rupal S. Bhatt(Beth Israel Deaconess Medical Center), Beatrice S. Knudsen(Cedars-Sinai Medical Center), Hua Xu(Tongji Hospital), Lily Wu(University of California, Los Angeles)
Molecular Therapy — Methods & Clinical Development
February 23, 2018
10.1016/j.omtm.2018.02.009
Cited by 38Open Access
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Abstract

) gene knockout RENCA cell line in BALB/c mice, generating an improved model of immunocompetent, metastatic renal cell carcinoma (RCC).

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