TADs are 3D structural units of higher-order chromosome organization in <i>Drosophila</i>
Quentin Szabo(Centre National de la Recherche Scientifique), Daniel Jost(Institut polytechnique de Grenoble), Jia‐Ming Chang(Centre National de la Recherche Scientifique), Diego I. Cattoni(Centre National de la Recherche Scientifique), Giorgio L. Papadopoulos(Centre National de la Recherche Scientifique), Boyan Bonev(Centre National de la Recherche Scientifique), Tom Sexton(Centre National de la Recherche Scientifique), Julian Gurgo(Centre National de la Recherche Scientifique), Caroline Jacquier(Centre National de la Recherche Scientifique), Marcelo Nöllmann(Centre National de la Recherche Scientifique), Frédéric Bantignies(Centre National de la Recherche Scientifique), Giacomo Cavalli(Centre National de la Recherche Scientifique)
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Abstract
. We observed that repressed TADs form a succession of discrete nanocompartments, interspersed by less condensed active regions. Single-cell analysis revealed a consistent TAD-based physical compartmentalization of the chromatin fiber, with some degree of heterogeneity in intra-TAD conformations and in cis and trans inter-TAD contact events. These results indicate that TADs are fundamental 3D genome units that engage in dynamic higher-order inter-TAD connections. This domain-based architecture is likely to play a major role in regulatory transactions during DNA-dependent processes.
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