Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging
Dena S. Leeman(Stanford University), Katja Hebestreit(Stanford University), Tyson J. Ruetz(Stanford University), Ashley E. Webb(Stanford University), Andrew McKay(Stanford University), Elizabeth A. Pollina(Stanford University), Ben W. Dulken(Stanford University), Xiaoai Zhao(Stanford University), Robin W. Yeo(Stanford University), Theodore Ho(Broad Center), Salah Mahmoudi(Stanford University), Keerthana Devarajan(Stanford University), Emmanuelle Passegué(Broad Center), Thomas A. Rando(Stanford University), Judith Frydman(Stanford University), Anne Brunet(Stanford University)
Cited by 555Open Access
Abstract
Lysosomes keep neuronal stem cells young An important consequence of aging is loss of regenerative capacity in stem cells, particularly those of the nervous system. Leeman et al. isolated quiescent and activated stem cells from mice and compared their transcriptomes. The findings emphasize the role of large lysosomes in quiescent neuronal stem cells in which aggregated proteins accumulate. Treatments that stimulated lysosomal function allowed aged quiescent stem cells to clear protein aggregates and restored the cells' ability to be activated. Such restoration of stem cell function might alleviate compromised proteostasis in aging. Science , this issue p. 1277
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