Hippocampal ripples down-regulate synapses
Hiroaki Norimoto(RIKEN Center for Brain Science), Kenichi Makino(The University of Tokyo), Mengxuan Gao(The University of Tokyo), Yu Shikano(The University of Tokyo), Kazuki Okamoto(The University of Tokyo), Tomoe Ishikawa(The University of Tokyo), Takuya Sasaki(The University of Tokyo), Hiroyuki Hioki(Kyoto University), Shigeyoshi Fujisawa(RIKEN Center for Brain Science), Yuji Ikegaya(The University of Tokyo)
Cited by 272
Abstract
Rebalancing mechanisms during sleep Synapses are often strengthened during wake periods and thus need to be homeostatically readjusted during sleep. During slow-wave sleep, synaptic depression is dominant. Sharp wave and ripple events are transient high-frequency field oscillations that occur spontaneously during slow-wave sleep in the brain. Norimoto et al. found that these events induced long-term depression of hippocampal synapses and may thus help to refine recently acquired memories (see the Perspective by Draguhn). Science , this issue p. 1524 ; see also p. 1461
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