Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria
Christine M. Dejea(Bloomberg (United States)), Payam Fathi(Bloomberg (United States)), John M. Craig(Johns Hopkins University), Annemarie Boleij(Bloomberg (United States)), Rahwa Taddese(Radboud University Nijmegen), Abby L. Geis(Bloomberg (United States)), Xinqun Wu(Bloomberg (United States)), Christina E. DeStefano Shields(Bloomberg (United States)), Elizabeth M. Hechenbleikner(Johns Hopkins University), David L. Huso(Johns Hopkins University), Robert A. Anders(Johns Hopkins University), Francis M. Giardiello(Johns Hopkins University), Elizabeth C. Wick(Johns Hopkins University), Hao Wang(Bloomberg (United States)), Shaoguang Wu(Bloomberg (United States)), Drew M. Pardoll(Bloomberg (United States)), Franck Housseau(Bloomberg (United States)), Cynthia L. Sears(Bloomberg (United States))
Cited by 1,095Open Access
Abstract
Biofilms provide refuge for cancerous bacteria Familial adenomatous polyposis (FAP) causes benign polyps along the colon. If left untreated, FAP leads to a high incidence of colon cancer. To understand how polyps influence tumor formation, Dejea et al. examined the colonic mucosa of FAP patients. They discovered biofilms containing the carcinogenic versions of the bacterial species Escherichia coli and Bacteroides fragilis . Colon tissue from FAP patients exhibited greater expression of two bacterial genes that produce secreted oncotoxins. Studies in mice showed that specific bacteria could work together to induce colon inflammation and tumor formation. Science , this issue p. 592
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