Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Sebastian Mueller; Thomas Engleitner; Roman Maresch; Magdalena Żukowska; Sebastian Lange; Thorsten Kaltenbacher; Björn Konukiewitz; Rupert Öllinger; Maximilian Zwiebel; Alex Strong; Hsi-Yu Yen; Ruby Banerjee; Sandra Louzada; Beiyuan Fu; Barbara Seidler; Juliana Götzfried; Kathleen Schuck; Zonera Hassan; Andreas Arbeiter; Nina Schönhuber; Sabine Klein; Christian Veltkamp; Mathias Friedrich; Lena Rad; Maxim Barenboim; Christoph Ziegenhain; Julia Heß; Oliver M. Dovey; Stefan Eser; Swati Parekh; Fernando Constantino‐Casas; Jorge de la Rosa; Marta Sierra; Mario F. Fraga; Julia Mayerle; Günter Klöppel; Juan Cadiñanos; Pentao Liu; George S. Vassiliou; Wilko Weichert; Katja Steiger; Wolfgang Enard; Roland M. Schmid; Fengtang Yang; Kristian Unger; Günter Schneider; Ignacio Varela; Allan Bradley; Dieter Saur; Roland Rad

doi:10.1038/nature25459

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Sebastian Mueller(TUM Klinikum), Thomas Engleitner(German Cancer Research Center), Roman Maresch(German Cancer Research Center), Magdalena Żukowska(TUM Klinikum), Sebastian Lange(TUM Klinikum), Thorsten Kaltenbacher(German Cancer Research Center), Björn Konukiewitz(Technical University of Munich), Rupert Öllinger(TUM Klinikum), Maximilian Zwiebel(TUM Klinikum), Alex Strong(Wellcome Sanger Institute), Hsi-Yu Yen(German Cancer Research Center), Ruby Banerjee(Wellcome Sanger Institute), Sandra Louzada(Wellcome Sanger Institute), Beiyuan Fu(Wellcome Sanger Institute), Barbara Seidler(TUM Klinikum), Juliana Götzfried(TUM Klinikum), Kathleen Schuck(TUM Klinikum), Zonera Hassan(TUM Klinikum), Andreas Arbeiter(TUM Klinikum), Nina Schönhuber(TUM Klinikum), Sabine Klein(TUM Klinikum), Christian Veltkamp(TUM Klinikum), Mathias Friedrich(Wellcome Sanger Institute), Lena Rad(TUM Klinikum), Maxim Barenboim(German Cancer Research Center), Christoph Ziegenhain(Ludwig-Maximilians-Universität München), Julia Heß(Helmholtz Zentrum München), Oliver M. Dovey(Wellcome Sanger Institute), Stefan Eser(TUM Klinikum), Swati Parekh(Ludwig-Maximilians-Universität München), Fernando Constantino‐Casas(University of Cambridge), Jorge de la Rosa(Universidad de Oviedo), Marta Sierra(Universidad de Oviedo), Mario F. Fraga(Universidad de Oviedo), Julia Mayerle(LMU Klinikum), Günter Klöppel(Technical University of Munich), Juan Cadiñanos(Wellcome Sanger Institute), Pentao Liu(Wellcome Sanger Institute), George S. Vassiliou(Wellcome Sanger Institute), Wilko Weichert(German Cancer Research Center), Katja Steiger(Technical University of Munich), Wolfgang Enard(Ludwig-Maximilians-Universität München), Roland M. Schmid(German Cancer Research Center), Fengtang Yang(Wellcome Sanger Institute), Kristian Unger(Helmholtz Zentrum München), Günter Schneider(German Cancer Research Center), Ignacio Varela(Instituto de Biomedicina y Biotecnología de Cantabria), Allan Bradley(Wellcome Sanger Institute), Dieter Saur(German Cancer Research Center), Roland Rad(German Cancer Research Center)

Nature

January 24, 2018

10.1038/nature25459

Cited by 442Open Access

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