CX3CR1 <sup>+</sup> mononuclear phagocytes control immunity to intestinal fungi

Irina Leonardi(Cornell University), Xin Li(Cornell University), Alexa Semon(Cornell University), Dalin Li(Cedars-Sinai Medical Center), Itai Doron(Cornell University), Gregory Putzel(Cornell University), Agnieszka S. Bar(Cornell University), Daniel Prieto(Universidad Complutense de Madrid), María Rescigno(European Institute of Oncology), Dermot McGovern(Cedars-Sinai Medical Center), Jesús Plá(Universidad Complutense de Madrid), Iliyan D. Iliev(Cornell University)
Science
January 12, 2018
10.1126/science.aao1503
Cited by 282

Abstract

Phagocytes patrol intestinal fungi Maintaining a healthy balance of gut bacteria can promote good health. Leonardi et al. show that fungi can also interact with gut immune cells to maintain intestinal well-being. CX3CR1 + mononuclear phagocytes (MNPs) patrol the intestine and promote antifungal immunity. Genetic deletion of CX3CR1 in MNPs caused colitis-like symptoms in mice. CX3CR1 polymorphisms were detected in Crohn's disease patients that were unable to produce antibodies against multiple fungal species. Thus, commensal fungi may be as important as bacteria in maintaining gut health, and antifungal therapy could hold promise for treating intestinal inflammation. Science , this issue p. 232

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