PD-1 inhibits the TCR signaling cascade by sequestering SHP-2 phosphatase, preventing its translocation to lipid rafts and facilitating Csk-mediated inhibitory phosphorylation of Lck.
Kankana Bardhan(Seres Therapeutics (United States)), Vassiliki A. Boussiotis(Beth Israel Deaconess Medical Center), Nikolaos Patsoukis(Beth Israel Deaconess Medical Center), Jessica D. Weaver(Arizona State University), Gordon J. Freeman(Dana-Farber Cancer Institute), Le‐Qun Li(Beth Israel Deaconess Medical Center)
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