Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia
Bing Chen(Shanghai Jiao Tong University), Lu Jiang(Shanghai Jiao Tong University), Meng‐Ling Zhong(Shanghai Jiao Tong University), Jianfeng Li(Shanghai Jiao Tong University), Ben-Shang Li(Shanghai Jiao Tong University), Lijun Peng(Shanghai Jiao Tong University), Yu-Ting Dai(Shanghai Jiao Tong University), Bowen Cui(Shanghai Jiao Tong University), Tian-Qi Yan(Shanghai Jiao Tong University), Weina Zhang(Shanghai Jiao Tong University), Xiangqin Weng(Shanghai Jiao Tong University), Yinyin Xie(Shanghai Jiao Tong University), Jing Lu(Shanghai Jiao Tong University), Ruibao Ren(Shanghai Jiao Tong University), Suning Chen(Shanghai Jiao Tong University), Jianda Hu(Fujian Medical University), Depei Wu(Soochow University), Chen Zhu(Shanghai Jiao Tong University), Jingyan Tang(Shanghai Jiao Tong University), Jin-Yan Huang(Shanghai Jiao Tong University), Jian‐Qing Mi(Shanghai Jiao Tong University), Sai‐Juan Chen(Shanghai Jiao Tong University)
Cited by 148Open Access
Abstract
Significance To get more insights into the disease mechanism of T-cell acute lymphoblastic leukemia (T-ALL), particularly in an adult group, we addressed the genomic landscape in 130 patients, including 61 cases of adult T-ALL. A number of new genetic aberrations were identified using integrated transcriptome and genomic analysis. Distinct T-ALL subgroups were defined according to the interplay among different genetic abnormalities and gene transcription patterns. Characterization of genomic features of T-ALL is valuable not only for a better understanding of leukemogenesis, but also for patient stratification and tailored therapy.
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