The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes
Dong Ding(Institute of Molecular Biology), Philipp Bergmaier(Institute of Molecular Biology), Parysatis Sachs(Institute of Molecular Biology), Marius Klangwart(Philipps University of Marburg), Tamina Rückert(Institute of Molecular Biology), Nora Bartels(Philipps University of Marburg), Jeroen Demmers(Erasmus MC), Mike R. Dekker(Erasmus MC), Raymond A. Poot(Erasmus MC), Jacqueline E. Mermoud(Institute of Molecular Biology)
Cited by 43Open Access
Abstract
Accordingly, an intact CUE1 domain was required for tethering this remodeler to the nucleus. Moreover, mutation of the CUE1 domain compromised SMARCAD1 binding to KAP1 target genes. Taken together, our results reveal a mechanism that localizes SMARCAD1 to genomic sites through the interaction of SMARCAD1's CUE1 motif with KAP1.
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