Myc Cooperates with Ras by Programming Inflammation and Immune Suppression

Roderik M. Kortlever(University of California, San Francisco), Nicole M. Sodir(University of California, San Francisco), Catherine H. Wilson(University of Cambridge), Deborah L. Burkhart(University of Cambridge), Luca Pellegrinet(University of Cambridge), Lamorna Brown Swigart(University of California, San Francisco), Trevor D. Littlewood(University of Cambridge), Gérard I. Evan(University of California, San Francisco)
Cell
November 1, 2017
Cited by 560Open Access
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Abstract

T cells but substantially dependent on returning NK cells. We show that Myc extensively programs an immune suppressive stroma that is obligatory for tumor progression.


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