A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

Niko Amin-Wetzel(University of Cambridge), Reuben A. Saunders(University of Cambridge), Maarten J. Kamphuis(University of Cambridge), Cláudia Rato(University of Cambridge), Steffen Preißler(University of Cambridge), Heather P. Harding(University of Cambridge), David Ron(University of Cambridge)
Cell
November 30, 2017
10.1016/j.cell.2017.10.040
Cited by 252Open Access
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Abstract

to its default, dimeric, and active state. These observations establish BiP and its J domain co-chaperones as key regulators of the UPR.

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