BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions
Maryam K. Fard(Max Planck Institute of Experimental Medicine), Franziska van der Meer(University of Göttingen), Paula Sánchez(Max Planck Institute of Experimental Medicine), Ludovico Cantuti‐Castelvetri(Max Planck Institute of Experimental Medicine), Sunit Mandad(Max Planck Institute for Biophysical Chemistry), Sarah Jäkel(Ludwig-Maximilians-Universität München), Eugenio F. Fornasiero(University of Göttingen), Sebastian Schmitt(Max Planck Institute of Experimental Medicine), Marc Ehrlich(University Hospital Münster), Laura Starost(University Hospital Münster), Tanja Kuhlmann(Max Planck Institute for Molecular Biomedicine), Christina Sergiou(University of Göttingen), Verena Schultz(University of Göttingen), Claudia Wrzos(University of Göttingen), Wolfgang Brück(University of Göttingen), Henning Urlaub(Max Planck Institute for Biophysical Chemistry), Leda Dimou(Universität Ulm), Christine Stadelmann(University of Göttingen), Mikael Simons(German Center for Neurodegenerative Diseases)
Cited by 244Open Access
Abstract
oligodendrocytes are reformed after experimental demyelination and found in a proportion of chronic white matter lesions of patients with multiple sclerosis (MS) even in a subset of patients with advanced disease. Our work identifies a means to map ongoing myelin formation in health and disease and presents a potential cellular target for remyelination therapies in MS.
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