A role for bacterial urease in gut dysbiosis and Crohn’s disease
Josephine Ni(University of Pennsylvania), Ting‐Chin David Shen(University of Pennsylvania), Eric Z. Chen(University of Pennsylvania), Kyle Bittinger(Children's Hospital of Philadelphia), Aubrey Bailey(University of Pennsylvania), Manuela Roggiani(University of Pennsylvania), Alexandra Sirota‐Madi(Broad Institute), Elliot S. Friedman(University of Pennsylvania), Lillian Chau(University of Pennsylvania), Andrew Lin(University of Pennsylvania), Ilana Nissim(Children's Hospital of Philadelphia), Justin Scott(Broad Institute), Abigail Lauder(University of Pennsylvania), Christian Hoffmann(University of Pennsylvania), Gloriany Rivas(University of Pennsylvania), Lindsey Albenberg(University of California, Los Angeles), Robert N. Baldassano(University of California, Los Angeles), Jonathan Braun(Harvard University), Ramnik J. Xavier(Broad Institute), Clary B. Clish(Broad Institute), Marc Yudkoff(Children's Hospital of Philadelphia), Hongzhe Li(University of Pennsylvania), Mark Goulian(University of Pennsylvania), Frederic D. Bushman(University of Pennsylvania), James D. Lewis(University of Pennsylvania), Gary D. Wu(University of Pennsylvania)
Cited by 231Open Access
Abstract
engineered to express urease led to dysbiosis of the gut microbiota, resulting in a predominance of Proteobacteria species. This was associated with a worsening of immune-mediated colitis in these animals. A potential role for altered urease expression and nitrogen flux in the development of gut dysbiosis suggests that bacterial urease may be a potential therapeutic target for inflammatory bowel diseases.
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