Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update
Ursula Amstutz(University of Bern), Linda M. Henricks(The Netherlands Cancer Institute), Steven M. Offer(Mayo Clinic), Julia M. Barbarino(Stanford University), Jan H.M. Schellens(Utrecht University), Jesse J. Swen(Leiden University Medical Center), Teri E. Klein(Stanford University), Howard L. McLeod(Moffitt Cancer Center), Kelly E. Caudle(St. Jude Children's Research Hospital), Robert B. Diasio(Mayo Clinic), Matthias Schwab(Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology)
Cited by 650Open Access
Abstract
The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase ( DPYD ) genotype tests so that the results can be used to guide dosing of fluoropyrimidines (5‐fluorouracil and capecitabine). Detailed guidelines for the use of fluoropyrimidines, their clinical pharmacology, as well as analyses of cost‐effectiveness are beyond the scope of this document. The Clinical Pharmacogenetics Implementation Consortium (CPIC ® ) guidelines consider the situation of patients for which genotype data are already available (updates available at https://cpicpgx.org/guidelines/guideline‐for‐fluoropyrimidines‐and‐dpyd/ ).
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