AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer
Hong Zhu(Zhejiang University), Lin-Lin CHANG(Zhejiang University), Fangjie Yan(Zhejiang University), Yan Hu(Zhejiang University), Chenming Zeng(Zhejiang University), Tianyi Zhou(Zhejiang University), Tao Yuan(Zhejiang University), Meidan Ying(Zhejiang University), Ji Cao(Zhejiang University), Qiaojun He(Zhejiang University), Bo Yang(Zhejiang University)
Cited by 93Open Access
Abstract
taken together, we show that AKR1C1 is a potent inducer of NSCLC metastasis. Our study uncovers the active function of AKR1C1 as a key component of the STAT3 pathway, which promotes lung cancer metastasis, and highlights a candidate therapeutic target to potentially improve the survival of NSCLC patients with metastatic disease.
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