Antiproliferative Dimeric Aporphinoid Alkaloids from the Roots of <i>Thalictrum cultratum</i>
Dahong Li(Shenyang Pharmaceutical University), Jianyong Li(Shenyang Pharmaceutical University), Chunmei Xue(Shenyang Pharmaceutical University), Tong Han(Shenyang Pharmaceutical University), Chunmei Sai(Shenyang Pharmaceutical University), Kai‐Bo Wang(Shenyang Pharmaceutical University), Jincai Lu(Shenyang Pharmaceutical University), Yongkui Jing(Shenyang Pharmaceutical University), Huiming Hua(Shenyang Pharmaceutical University), Zhan‐Lin Li(Shenyang Pharmaceutical University)
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Abstract
value of 1.06 μM against HL-60 cells, was selected for mechanism of action studies. The results revealed that compound 3 induced apoptosis and arrested the HL-60 cell cycle at the S phase with the loss of mitochondria membrane potential. The nuclear morphological Hoechst 33258 staining assay was also carried out, and the results confirmed apoptosis.
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