An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Asís Palazón; Petros A. Tyrakis; David Macías; Pedro Veliça; Helene Rundqvist; Susan F. Fitzpatrick; Nikola Vojnović; Anthony T. Phan; Niklas Loman; Ingrid Hedenfalk; Thomas Hatschek; John Lövrot; Theodoros Foukakis; Ananda W. Goldrath; Jonas Bergh; Randall S. Johnson

doi:10.1016/j.ccell.2017.10.003

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Asís Palazón(University of Cambridge), Petros A. Tyrakis(University of Cambridge), David Macías(Cancer Research UK Cambridge Center), Pedro Veliça(Karolinska Institutet), Helene Rundqvist(Karolinska Institutet), Susan F. Fitzpatrick(Cancer Research UK Cambridge Center), Nikola Vojnović(Karolinska Institutet), Anthony T. Phan(University of California San Diego), Niklas Loman(Lund University), Ingrid Hedenfalk(Lund University), Thomas Hatschek(Karolinska University Hospital), John Lövrot(Karolinska University Hospital), Theodoros Foukakis(Karolinska University Hospital), Ananda W. Goldrath(University of California San Diego), Jonas Bergh(Karolinska University Hospital), Randall S. Johnson(University of Cambridge)

Cancer Cell

November 1, 2017

10.1016/j.ccell.2017.10.003

Cited by 525Open Access

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Abstract

T cell infiltration, and a link between T cell infiltration and vascularization. These data demonstrate that the HIF-1α/VEGF-A axis is an essential aspect of tumor immunity.

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