Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity

Houjun Xia(University of Michigan), Wei Wang(Peking University), Joel Crespo(University of Michigan), Ilona Kryczek(University of Michigan), Wei Li(University of Michigan), Shuang Wei(University of Michigan), Zhaoqun Bian(University of Michigan), Tomasz Maj(University of Michigan), Ming‐Xiao He(Duke University), J Rebecca Liu(University of Michigan), You‐Wen He(Duke University), Ramandeep Rattan(Henry Ford Health System), Adnan Munkarah(Henry Ford Health System), Jun‐Lin Guan(University of Cincinnati Medical Center), Weiping Zou(University of Michigan)
Science Immunology
November 17, 2017
Cited by 146

Abstract

Tumor-derived lactate induced naïve T cell apoptosis via suppressing FIP200 expression and autophagy formation, resulting in mitochondria activation and imbalance of Bcl-2 family members in T cells.


Related Papers

No related papers found

Powered by citation graph analysis