Chemical Biology of H<sub>2</sub>S Signaling through Persulfidation
Miloš R. Filipović(Centre National de la Recherche Scientifique), Jasmina Živanović(Centre National de la Recherche Scientifique), Beatriz Álvarez(Universidad de la República de Uruguay), Ruma Banerjee(University of Michigan)
Cited by 1,014
Abstract
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.
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