Oral epithelial cells orchestrate innate type 17 responses to <i>Candida albicans</i> through the virulence factor candidalysin
Akash Verma(University of Pittsburgh), Jonathan P. Richardson(King's College London), Chunsheng Zhou(University of Pittsburgh), Bianca M. Coleman(University of Pittsburgh), David L. Moyes(King's College London), Jemima Ho(King's College London), Anna R. Huppler(Children's Hospital of Wisconsin), Kritika Ramani(University of Pittsburgh), Mandy J. McGeachy(University of Pittsburgh), Ilgiz A. Mufazalov(Johannes Gutenberg University Mainz), Ari Waisman(Johannes Gutenberg University Mainz), Larry Kane(University of Pittsburgh), Partha S. Biswas(University of Pittsburgh), Bernhard Hube(Jena University Hospital), Julian R. Naglik(King's College London), Sarah L. Gaffen(University of Pittsburgh)
Cited by 204Open Access
Abstract
, via secreted candidalysin, amplify inflammation in a self-reinforcing feed-forward loop. These findings challenge the paradigm that hyphal formation per se is required for the oral innate response and demonstrate that establishment of IL-1- and IL-17-dependent innate immunity is induced by tissue-damaging hyphae.
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