Assessment of tobacco heating product THP1.0. Part 2: Product design, operation and thermophysical characterisation

D. Eaton(British American Tobacco (United Kingdom)), Blerta Jakaj(British American Tobacco (United Kingdom)), Mark Forster(British American Tobacco (United Kingdom)), James Nicol(British American Tobacco (United Kingdom)), Eleni Mavropoulou(British American Tobacco (United Kingdom)), Kenneth W. Scott(British American Tobacco (United Kingdom)), Chuan Liu(British American Tobacco (United Kingdom)), Kevin McAdam(British American Tobacco (United Kingdom)), James J. Murphy(British American Tobacco (United Kingdom)), Christopher Proctor(British American Tobacco (United Kingdom))
Regulatory Toxicology and Pharmacology
October 25, 2017
Cited by 123Open Access
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Abstract

A novel tobacco heating product, THP1.0, that heats tobacco below 245 °C is described. It was designed to eliminate tobacco combustion, while heating tobacco to release nicotine, tobacco volatiles and glycerol to form its aerosol. The stewardship assessment approach behind the THP 1.0 design was based on established toxicological principles. Thermophysical studies were conducted to examine the extent of tobacco thermal conversion during operation. Thermogravimetric analysis of the tobacco material revealed the major thermal behaviour in air and nitrogen up to 900 °C. This, combined with the heating temperature profiling of the heater and tobacco rod, verified that the tobacco was not subject to combustion. The levels of tobacco combustion markers (CO, CO2, NO and NOx) in the aerosol of THP1.0 were significantly lower than the levels if there were any significant pyrolysis or combustion. Quantification of other tobacco thermal decomposition and evaporative transfer markers showed that these levels were, on average, reduced by more than 90% in THP1.0 aerosol as compared with cigarette smoke. The physical integrity of the tobacco consumable rod showed no ashing. Taken together, these data establish that the aerosol generated by THP1.0 is produced mainly by evaporation and distillation, and not by combustion or pyrolysis.


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