PGE <sub>2</sub> production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

Catherine A. Loynes; Jou A. Lee; Anne L. Robertson; Michael JG. Steel; Felix Ellett; Yi Feng; Bruce D. Levy; Moira K. B. Whyte; Stephen A. Renshaw

doi:10.1126/sciadv.aar8320

PGE <sub>2</sub> production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo

Catherine A. Loynes(University of Sheffield), Jou A. Lee(University of Sheffield), Anne L. Robertson(Boston Children's Hospital), Michael JG. Steel(University of Sheffield), Felix Ellett(Harvard University), Yi Feng(Centre for Inflammation Research), Bruce D. Levy(Brigham and Women's Hospital), Moira K. B. Whyte(Centre for Inflammation Research), Stephen A. Renshaw(University of Sheffield)

Science Advances

September 5, 2018

10.1126/sciadv.aar8320

Cited by 215Open Access

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Abstract

) in an in vivo model of inflammation resolution. This pathway may contain therapeutic targets for driving inflammation resolution in chronic inflammatory disease.

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