Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol

on behalf of the International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG)(Princess Máxima Center), Marry M. van den Heuvel‐Eibrink(Princess Máxima Center), Janna A. Hol(Princess Máxima Center), Kathy Pritchard‐Jones(The Netherlands Cancer Institute), Harm van Tinteren(The Netherlands Cancer Institute), Rhoikos Furtwängler(Hôpital de la Timone), Arnauld Verschuur(University Hospital of Wales), Gordan Vujanić(University Hospital of Wales), Ivo Leuschner(Christian-Albrechts-Universität zu Kiel), Jesper Brok(University College London), Christian Rübe(Amsterdam UMC Location University of Amsterdam), Anne Smets(Heidelberg University), Geert O. Janssens(Heidelberg University), Jan Godziński(Wroclaw Medical University), Gema Ramírez(Instituto Nacional de Câncer - INCA), Beatriz de Camargo(Instituto Nacional de Câncer - INCA), Heidi Segers(Fondazione IRCCS Istituto Nazionale dei Tumori), Paola Collini(Comprehensive Cancer Center Mainfranken), Manfred Gessler(Institut d’Hématologie et d’Oncologie Pédiatrique), Christophe Bergeron(Institut d’Hématologie et d’Oncologie Pédiatrique), Filippo Spreafico(Fondazione IRCCS Istituto Nazionale dei Tumori), Norbert Graf(Saarland University)
Nature Reviews Urology
October 31, 2017
10.1038/nrurol.2017.163
Cited by 375Open Access
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Abstract

The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the UMBRELLA protocol). In this Consensus Statement, members of SIOP–RTSG outline the rationale for the recommendations in the protocol. The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP–RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP–RTSG best available treatment standard.

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