α-Glucosidase inhibition by flavonoids: an<i>in vitro</i>and<i>in silico</i>structure–activity relationship study

Carina Proença(Universidade do Porto), Marisa Freitas(Universidade do Porto), Daniela Ribeiro(Universidade do Porto), Eduardo F. Oliveira(Universidade do Porto), Joana L. C. Sousa(University of Aveiro), Sara M. Tomé(University of Aveiro), Maria J. Ramos(Universidade do Porto), Artur M. S. Silva(University of Aveiro), Pedro Alexandrino Fernandes(Universidade do Porto), Eduarda Fernandes(Universidade do Porto)
Journal of Enzyme Inhibition and Medicinal Chemistry
January 1, 2017
10.1080/14756366.2017.1368503
Cited by 398Open Access
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Abstract

much lower than the one found for the most widely prescribed α-glucosidase inhibitor, acarbose. The present work suggests that several of the studied flavonoids have the potential to be used as alternatives for the regulation of PPHG.

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