Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy
Kevin A. Hay(University of British Columbia), Laïla‐Aïcha Hanafi(Fred Hutch Cancer Center), Daniel Li, Juliane Gust(Seattle Children's Hospital), W. Conrad Liles(University of Washington), Mark M. Wurfel(University of Washington), José A. López(University of Washington), Junmei Chen(Bloodworks Northwest), Dominic W. Chung(Bloodworks Northwest), Susanna Harju-Baker(University of Washington), Sindhu Cherian(University of Washington), Xueyan Chen(University of Washington), Stanley R. Riddell(University of Washington), David G. Maloney(University of Washington), Cameron J. Turtle(University of Washington)
Cited by 1,102Open Access
Abstract
central memory T cells as independent predictors of CRS. Severe CRS was characterized by hemodynamic instability, capillary leak, and consumptive coagulopathy. Angiopoietin-2 and von Willebrand factor, which are biomarkers of endothelial activation, were increased during severe CRS and also before lymphodepletion in patients who subsequently developed CRS. We describe a classification-tree algorithm to guide studies of early intervention after CAR T-cell infusion for patients at high risk of severe CRS. These data provide a framework for early intervention studies to facilitate safer application of effective CD19 CAR T-cell therapy.
Related Papers
No related papers found
Powered by citation graph analysis