Mast cell exosomes can suppress allergic reactions by binding to IgE
Guogang Xie(Shanghai Jiao Tong University), Haiwei Yang(Jiangsu Province Hospital), Peng Xia(Shanghai Jiao Tong University), Lihui Lin(Shanghai Jiao Tong University), Juan Wang(Shanghai Jiao Tong University), Kun Lin(Shanghai Jiao Tong University), Zelin Cui(Shanghai Jiao Tong University), Li Jia(Shanghai Jiao Tong University), Hui Xiao(Shanghai Jiao Tong University), Yuting Liang(Shanghai Jiao Tong University), Li Li(Shanghai Jiao Tong University)
Cited by 72Open Access
Abstract
Allergic diseases are characterized by the increased serum levels of total IgE and specific IgE against common allergens.1 After sensitization of susceptible individuals, the synthesis and binding of allergen-specific IgE to mast cells (MCs) via high-affinity IgE receptors (FcεRI), atopic individuals respond to allergens by releasing mast cell–derived mediators.2 Secreted by multiple cell types including MCs, exosomes are nano-sized, cell membrane–surrounded structures harboring a broad range of biomolecules linked to cell type–associated functions.
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