A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair
Yan Zeng(Sunnybrook Research Institute), William W. Du(University of Toronto), Yingya Wu(Sunnybrook Health Science Centre), Zhenguo Yang(Health Sciences Centre), Faryal Mehwish Awan(Sunnybrook Research Institute), Xiangmin Li(University of Toronto), Weining Yang(Health Sciences Centre), Chao Zhang(Health Sciences Centre), Qi Yang(Sunnybrook Health Science Centre), Albert Yee(Health Sciences Centre), Yú Chen, Fenghua Yang(Guangdong Laboratory Animals Monitoring Institute), Huan Sun(University Health Network), Ren Huang(Guangdong Laboratory Animals Monitoring Institute), Albert Yee(Sunnybrook Health Science Centre), Ren‐Ke Li(University Health Network), Zhongkai Wu, Peter H. Backx(University Health Network), Burton B. Yang(Health Sciences Centre)
Cited by 423Open Access
Abstract
. Blocking oligonucleotides could reverse the effects of exogenous circ-Amotl1. We conclude that circ-Amotl1 physically binds to both PDK1 and AKT1, facilitating the cardio-protective nuclear translocation of pAKT.
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