Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma

Christopher D. Carey(Brigham and Women's Hospital), Daniel Gusenleitner, Mikel Lipschitz, Margaretha G.M. Roemer(Dana-Farber Cancer Institute), Edward C. Stack(PerkinElmer (United States)), Evisa Gjini, Xihao Hu(Dana-Farber Cancer Institute), Robert Redd(Dana-Farber Cancer Institute), Gordon J. Freeman(Dana-Farber Cancer Institute), Donna Neuberg(Dana-Farber Cancer Institute), F. Stephen Hodi(Dana-Farber Cancer Institute), Xiaole Shirley Liu(Dana-Farber Cancer Institute), Margaret A. Shipp(Dana-Farber Cancer Institute), Scott J. Rodig(Brigham and Women's Hospital)
Blood
September 12, 2017
10.1182/blood-2017-03-770719
Cited by 331Open Access
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Abstract

Key Points Regionally localized PD-L1+ macrophages form a specialized microenvironmental niche for Hodgkin Reed-Sternberg cells in cHL.

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