In Situ Fluorogenic and Chromogenic Reactions for the Sensitive Dual-Readout Assay of Tyrosinase Activity
Jiahui Zhao(Chinese Academy of Sciences), Xingfu Bao(Chinese Academy of Sciences), Shuang Wang(University of Science and Technology of China), Shasha Lu(University of Science and Technology of China), Jian Sun(Chinese Academy of Sciences), Xiurong Yang(Chinese Academy of Sciences)
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Abstract
, where the absorbance and fluorescence intensity are directly related to the concentration of added tyrosinase (i.e., the amount of conversion of tyramine to dopamine). The overall process of sensing tyrosinase activity takes less than 100 min at ambient temperature and pressure conditions with exceedingly simple operation procedure, explicit response mechanism, and formation of fluorophore with high quantum yield from scratch. Furthermore, such a convenient, rapid, cost-effective, and highly sensitive dual-readout assay exhibits promising prospect for the tyrosinase activity in extensive bioassays and clinic research as well as in screening potential tyrosinase inhibitors.
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