Epidemiology and Antifungal Susceptibilities of Yeast Isolates Causing Invasive Infections Across Urban Beijing, China

Lina Guo(Chinese Academy of Medical Sciences & Peking Union Medical College), Meng Xiao(Chinese Academy of Medical Sciences & Peking Union Medical College), Bin Cao(Capital Medical University), Fen Qu(Peking University), Yuliang Zhan(Beijing University of Chinese Medicine), Yunjian Hu(Peking University), Xinru Wang(Air Force General Hospital PLA), Guowei Liang(Peking University), Haitong Gu(Beijing Tongren Hospital), Jun Qi(Chinese Academy of Medical Sciences & Peking Union Medical College), Hui Yuan(Capital Medical University), Rong Min(Capital Medical University), Feiyan Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Lin-Juan Liu(Peking University), Haibin Wang(Second Military Medical University), Wei Jiang(Second Military Medical University), Xueguang Duan(Beijing University of Chinese Medicine), Wenjian Xu(Children's Hospital of Capital Institute of Pediatrics), Yanhua Yu(Capital Medical University), Jianrong Su(Capital Medical University), Jian-Zhong Zhang(National Institute for Communicable Disease Control and Prevention), Jinqing Nong(Peking University Shougang Hospital), Shumei Liu(Capital Medical University), Jun Li(Jiangxi University of Traditional Chinese Medicine), Junting Liu(Capital Medical University), Zhigang Yue(Meitan General Hospital), Duo Yang(Capital Medical University), Jie Guo(Chinese Academy of Medical Sciences & Peking Union Medical College), Rui Zhao(State Grid Corporation of China (China)), Yanan Zhang(Capital Medical University), Xi-Ming Yang(Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine), Xiaoqing Liu(Chinese Academy of Medical Sciences & Peking Union Medical College), Po‐Ren Hsueh(National Taiwan University Hospital), Yingchun Xu(Chinese Academy of Medical Sciences & Peking Union Medical College)
Future Microbiology
August 24, 2017
10.2217/fmb-2017-0036
Cited by 26

Abstract

AIM: To investigate the species distribution and antifungal susceptibility profiles of yeast isolates causing invasive infections across Beijing. MATERIALS & METHODS: A total of 1201 yeast isolates recovered from blood and other sterile body fluids were correctly identified by matrix-assisted laser desorption/ionization TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute broth microdilution method. RESULTS: Candida (95.5%) remained the most common yeast species isolated; Candida albicans (38.8%) and Candida parapsilosis (22.6%) were the leading species of candidemia. Azole resistances were mainly observed in Candida glabrata and Candida tropicalis isolates. CONCLUSION: This study outlined the epidemiologic data of invasive yeast infections and highlighted the need for continuous monitoring of azole resistances among C. glabrata and C. tropicalis isolates in Beijing.

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