Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow
Vasilios A. Morikis(University of California, Davis), Shannon Chase(University of California, Davis), Ted Wun(VA Northern California Health Care System), Elliot L. Chaikof(Beth Israel Deaconess Medical Center), John L. Magnani(GlycoMimetics (United States)), Scott I. Simon(University of California, Davis)
Cited by 95Open Access
Abstract
Key Points Neutrophils rolling on E-selectin form catch-bonds with L-selectin that mechanosignal β2-integrin bond formation with intracellular adhesion molecule 1. Rivipansel blocks E-selectin recognition of sLex on L-selectin, thereby antagonizing outside-in signaling of high-affinity β2-integrin.
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