Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient
Alejandro Jiménez-Sánchez(University of Cambridge), Danish Memon(European Bioinformatics Institute), Stephane Pourpe(Memorial Sloan Kettering Cancer Center), Harini Veeraraghavan(Memorial Sloan Kettering Cancer Center), Yanyun Li(Memorial Sloan Kettering Cancer Center), Hebert Alberto Vargas(Memorial Sloan Kettering Cancer Center), Michael B. Gill(University of Cambridge), Kay J. Park(Memorial Sloan Kettering Cancer Center), Oliver Zivanovic(Memorial Sloan Kettering Cancer Center), Jason Konner(Memorial Sloan Kettering Cancer Center), Jacob Ricca(Memorial Sloan Kettering Cancer Center), Dmitriy Zamarin(Memorial Sloan Kettering Cancer Center), Tyler Walther(Memorial Sloan Kettering Cancer Center), Carol Aghajanian(Memorial Sloan Kettering Cancer Center), Jedd D. Wolchok(Memorial Sloan Kettering Cancer Center), Evis Sala(Memorial Sloan Kettering Cancer Center), Taha Merghoub(Memorial Sloan Kettering Cancer Center), Alexandra Snyder(Memorial Sloan Kettering Cancer Center), Martin L. Miller(University of Cambridge)
Cited by 462Open Access
Abstract
T cell reactivity against predicted neoepitopes after isolation of cells from a blood sample taken almost 3 years after the tumors were resected. These findings suggest that multiple distinct tumor immune microenvironments co-exist within a single individual and may explain in part the heterogeneous fates of metastatic lesions often observed in the clinic post-therapy. VIDEO ABSTRACT.
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