Anti-CD19 CAR T Cells in CNS Diffuse Large-B-Cell Lymphoma

Jeremy S. Abramson(Massachusetts General Hospital), Brianne McGree(Massachusetts General Hospital), Sarah Noyes(Massachusetts General Hospital), Sean Plummer(Massachusetts General Hospital), Curtis Wong(Massachusetts General Hospital), Yi‐Bin Chen(Massachusetts General Hospital), Edwin L. Palmer(Massachusetts General Hospital), Tina Albertson, Judith A. Ferry(Massachusetts General Hospital), Isabel Arrillaga‐Romany(Massachusetts General Hospital)
New England Journal of Medicine
August 23, 2017
Cited by 210Open Access
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Abstract

In this case, a woman with refractory diffuse large-B-cell lymphoma had a CNS recurrence that responded completely to anti-CD19 CAR T-cell therapy. After biopsy of a subsequent skin recurrence, the lesions cleared in association with an expansion of the CAR T cells in the blood.


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